In my humble opinion (I'm new) if you find a table that gets you what you need even if you have to use several fields, consider that a win. I use S2301 because that's what I found was the best for the labor force. I also look at S2303 hours worked, S2401 service industry, B99087 worked from home as these are often used and are also interesting. Pulling from the API is very easy and only gives you the fields you want, so hopefully, you're using these (you can group like tables into one API, just note there are exceptions and not all tables with the same letter code are necessarily the same.
These are the subject tables and fields I use (if it helps), this example is for all counties ACS1, just edit ACS1 to acs5 and it works great.
https://api.census.gov/data/2021/acs/acs1/subject?get=S0101_C01_001E,S0101_C01_030E,S0101_C01_032E,S0101_C02_002E,S0101_C02_022E,S0101_C02_026E,S0101_C05_001E,S1101_C01_002E,S1101_C01_004E,S1101_C01_019E,S1501_C02_005E,S1501_C02_015E,S1701_C03_001E,S1701_C03_002E,S1701_C03_003E,S1701_C03_010E,S1901_C01_002E,S1901_C01_011E,S1901_C01_013E,S2101_C04_001E,S2201_C04_001E,S2301_C02_001E,S2301_C04_001E,S2303_C01_031E,S2401_C01_018E,S2701_C01_017E,S2701_C01_023E,S2701_C01_024E,S2701_C01_032E,S2701_C01_035E,S2701_C05_001E,S2701_C05_002E,S2701_C05_011E,NAME&for=county:*
| S0101_C01_001E | Estimate!!Total!!Total population |
| S0101_C01_030E | Estimate!!Total!!Total population!!SELECTED AGE CATEGORIES!!65 years and over |
| S0101_C01_032E | Estimate!!Total!!Total population!!SUMMARY INDICATORS!!Median age (years) |
| S0101_C02_002E | Estimate!!Percent!!Total population!!AGE!!Under 5 years |
| S0101_C02_022E | Estimate!!Percent!!Total population!!SELECTED AGE CATEGORIES!!Under 18 years |
| S0101_C02_026E | Estimate!!Percent!!Total population!!SELECTED AGE CATEGORIES!!18 years and over |
| S0101_C05_001E | Estimate!!Female!!Total population |
| S1101_C01_002E | Estimate!!Total!!HOUSEHOLDS!!Average household size |
| S1101_C01_004E | Estimate!!Total!!FAMILIES!!Average family size |
| S1101_C01_019E | Estimate!!Total!!Total households!!HOUSING TENURE!!Renter-occupied housing units |
| S1501_C02_005E | Estimate!!Percent!!AGE BY EDUCATIONAL ATTAINMENT!!Population 18 to 24 years!!Bachelor's degree or higher |
| S1501_C02_015E | Estimate!!Percent!!AGE BY EDUCATIONAL ATTAINMENT!!Population 25 years and over!!Bachelor's degree or higher |
| S1701_C03_001E | Estimate!!Percent below poverty level!!Population for whom poverty status is determined |
| S1701_C03_002E | Estimate!!Percent below poverty level!!Population for whom poverty status is determined!!AGE!!Under 18 years |
| S1701_C03_003E | Estimate!!Percent below poverty level!!Population for whom poverty status is determined!!AGE!!Under 18 years!!Under 5 years |
| S1701_C03_010E | Estimate!!Percent below poverty level!!Population for whom poverty status is determined!!AGE!!65 years and over |
| S1901_C01_002E | Estimate!!Households!!Total!!Less than $10,000 |
| S1901_C01_011E | Estimate!!Households!!Total!!$200,000 or more |
| S1901_C01_013E | Estimate!!Households!!Mean income (dollars) |
| S2101_C04_001E | Estimate!!Percent Veterans!!Civilian population 18 years and over |
| S2201_C04_001E | Estimate!!Percent households receiving food stamps/SNAP!!Households |
| S2301_C02_001E | Estimate!!Labor Force Participation Rate!!Population 16 years and over |
| S2301_C04_001E | Estimate!!Unemployment rate!!Population 16 years and over |
| S2303_C01_031E | Estimate!!Total!!Population 16 to 64 years!!Mean usual hours worked for workers |
| S2401_C01_018E | Estimate!!Total!!Civilian employed population 16 years and over!!Service occupations: |
| S2701_C01_017E | Estimate!!Total!!Civilian noninstitutionalized population!!RACE AND HISPANIC OR LATINO ORIGIN!!Black or African American alone |
| S2701_C01_023E | Estimate!!Total!!Civilian noninstitutionalized population!!RACE AND HISPANIC OR LATINO ORIGIN!!Hispanic or Latino (of any race) |
| S2701_C01_024E | Estimate!!Total!!Civilian noninstitutionalized population!!RACE AND HISPANIC OR LATINO ORIGIN!!White alone, not Hispanic or Latino |
| S2701_C01_032E | Estimate!!Total!!Civilian noninstitutionalized population!!NATIVITY AND U.S. CITIZENSHIP STATUS!!Foreign born |
| S2701_C01_035E | Estimate!!Total!!Civilian noninstitutionalized population!!DISABILITY STATUS!!With a disability |
| S2701_C05_001E | Estimate!!Percent Uninsured!!Civilian noninstitutionalized population |
| S2701_C05_002E | Estimate!!Percent Uninsured!!Civilian noninstitutionalized population!!AGE!!Under 6 years |
| S2701_C05_011E | Estimate!!Percent Uninsured!!Civilian noninstitutionalized population!!AGE!!Under 19 years |