Dear Steve,
Don't forget that the ACS is a survey and the numbers in the tables are survey/sample estimates. A census is a count of "everybody" and there is no "margin of error"
As a general matter you can look at tract level estimates and make any computation you want just make sure to carry the MoE along so you can look at the MoE for your estimate/combination. You will get an estimate and say a 95% confidence interval.
To do this correctly and get "exact" estimates for MoE you need to use Variance Replicate Estimate tables.
"The tables are intended for advanced users who are adding ACS data within a table or between geographies. Users can calculate margins of error for aggregated data by using the variance replicates. Unlike available approximation formulas, this method results in an exact margin of error by using the covariance term."
For details look here: https://www2.census.gov/programs-surveys/acs/replicate_estimates/2021/documentation/5-year/2017-2021_Variance_Replicate_Table_Documentation.pdf
A good book on Survey methodology which discusses the various methods used for ACS estimates:
www.amazon.com/.../
https://www.census.gov/programs-surveys/acs/data/variance-tables.html which are available for a subset of ACS 5 year "B" tables.
The reason the the ACS puts in the "Tips" is so that less sophisticated users don't "fall into any traps" when the compute and interpret ACS data.
With the Variance Replicate Estimate tables you can compute the MoE for any function of the table cells. A percentage, a square root, the cosine an exponential anything you want!
Hope that this gives you some insight into the "statistical technology" used with the ACS.
The take home is when you put an ACS estimate in a report put in a confidence interval Xx (low,high) or use a +- after your estimate or number. I have a trick. I always include one digit after the decimal point to indicate that the number is an estimate not a count of people -- you cant have a 1.3 of a person.